The Coronavirus in America: The Year Ahead – The New York Times

The Coronavirus in America: The Year Ahead

There will be no quick return to our previous lives, according to nearly two dozen experts. But there is hope for managing the scourge now and in the long term.

The coronavirus is spreading from America’s biggest cities to its suburbs, and has begun encroaching on the nation’s rural regions. The virus is believed to have infected millions of citizens and has killed more than 34,000.

Yet President Trump this week proposed guidelines for reopening the economy and suggested that a swath of the United States would soon resume something resembling normalcy. For weeks now, the administration’s view of the crisis and our future has been rosier than that of its own medical advisers, and of scientists generally.

In truth, it is not clear to anyone where this crisis is leading us. More than 20 experts in public health, medicine, epidemiology and history shared their thoughts on the future during in-depth interviews. When can we emerge from our homes? How long, realistically, before we have a treatment or vaccine? How will we keep the virus at bay?

Some felt that American ingenuity, once fully engaged, might well produce advances to ease the burdens. The path forward depends on factors that are certainly difficult but doable, they said: a carefully staggered approach to reopening, widespread testing and surveillance, a treatment that works, adequate resources for health care providers — and eventually an effective vaccine.

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Still, it was impossible to avoid gloomy forecasts for the next year. The scenario that Mr. Trump has been unrolling at his daily press briefings — that the lockdowns will end soon, that a protective pill is almost at hand, that football stadiums and restaurants will soon be full — is a fantasy, most experts said.

“We face a doleful future,” said Dr. Harvey V. Fineberg, a former president of the National Academy of Medicine.

He and others foresaw an unhappy population trapped indoors for months, with the most vulnerable possibly quarantined for far longer. They worried that a vaccine would initially elude scientists, that weary citizens would abandon restrictions despite the risks, that the virus would be with us from now on.

“My optimistic side says the virus will ease off in the summer and a vaccine will arrive like the cavalry,” said Dr. William Schaffner, a preventive medicine specialist at Vanderbilt University medical school. “But I’m learning to guard against my essentially optimistic nature.”

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Most experts believed that once the crisis was over, the nation and its economy would revive quickly. But there would be no escaping a period of intense pain.

Exactly how the pandemic will end depends in part on medical advances still to come. It will also depend on how individual Americans behave in the interim. If we scrupulously protect ourselves and our loved ones, more of us will live. If we underestimate the virus, it will find us.

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ImageRefrigerated trucks were used as mobile morgues on Randall’s Island in New York.static01.nyt.com/images/2020/04/19/science/18VIRUS-FUTURE2/merlin_171637683_2e5b6d03-b9c0-4671-bcc6-8f847fb7618d-jumbo.jpg?quality=90&auto=webp 1024w, static01.nyt.com/images/2020/04/19/science/18VIRUS-FUTURE2/merlin_171637683_2e5b6d03-b9c0-4671-bcc6-8f847fb7618d-superJumbo.jpg?quality=90&auto=webp 2048w” sizes=”100vw” decoding=”async” itemprop=”url” itemid=”https://static01.nyt.com/images/2020/04/19/science/18VIRUS-FUTURE2/merlin_171637683_2e5b6d03-b9c0-4671-bcc6-8f847fb7618d-articleLarge.jpg?quality=75&auto=webp&disable=upscale” style=”margin: 0px; padding: 0px; border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: top; height: auto; max-width: 100%; width: 414px; cursor: pointer;” data-unique-identifier=””>
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Covid-19, the illness caused by the coronavirus, is arguably the leading cause of death in the United States right now. The virus has killed more than 1,800 Americans almost every day since April 7, and the official toll may be an undercount.

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By comparison, heart disease typically kills 1,774 Americans a day, and cancer kills 1,641.

Yes, the coronavirus curves are plateauing. There are fewer hospital admissions in New York, the center of the epidemic, and fewer Covid-19 patients in I.C.U.s. The daily death toll is still grim, but no longer rising.

The epidemiological model often cited by the White House, which was produced by the University of Washington’s Institute for Health Metrics and Evaluation, originally predicted 100,000 to 240,000 deaths by midsummer. Now that figure is 60,000.

While this is encouraging news, it masks some significant concerns. The institute’s projection runs through Aug. 4, describing only the first wave of this epidemic. Without a vaccine, the virus is expected to circulate for years, and the death tally will rise over time.

The gains to date were achieved only by shutting down the country, a situation that cannot continue indefinitely. The White House’s “phased” plan for reopening will surely raise the death toll no matter how carefully it is executed. The best hope is that fatalities can be held to a minimum.

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Reputable longer-term projections for how many Americans will die vary, but they are all grim. Various experts consulted by the Centers for Disease Control and Prevention in March predicted that the virus eventually could reach 48 percent to 65 percent of all Americans, with a fatality rate just under 1 percent, and would kill up to 1.7 million of them if nothing were done to stop the spread.

A model by researchers at Imperial College London cited by the president on March 30 predicted 2.2 million deaths in the United States by September under the same circumstances.

By comparison, about 420,000 Americans died in World War II.

The limited data from China are even more discouraging. Its epidemic has been halted — for the moment — and virtually everyone infected in its first wave has died or recovered.

China has officially reported about 83,000 cases and 4,632 deaths, which is a fatality rate of over 5 percent. The Trump administration has questioned the figures but has not produced more accurate ones.

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Fatality rates depend heavily on how overwhelmed hospitals get and what percentage of cases are tested. China’s estimated death rate was 17 percent in the first week of January, when Wuhan was in chaos, according to a Center for Evidence-Based Medicine report, but only 0.7 percent by late February.

In this country, hospitals in several cities, including New York, came to the brink of chaos. Officials in both Wuhan and New Yorkhad to revise their death counts upward this week when they realized that many people had died at home of Covid-19, strokes, heart attacks or other causes, or because ambulances never came for them.

In fast-moving epidemics, far more victims pour into hospitals or die at home than doctors can test; at the same time, the mildly ill or asymptomatic never get tested. Those two factors distort the true fatality rate in opposite ways. If you don’t know how many people are infected, you don’t know how deadly a virus is.

Only when tens of thousands of antibody tests are done will we know how many silent carriers there may be in the United States. The C.D.C. has suggested it might be 25 percent of those who test positive. Researchers in Iceland said it might be double that.

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China is also revising its own estimates. In February, a major study concluded that only 1 percent of cases in Wuhan were asymptomatic. New research says perhaps 60 percent were. Our knowledge gaps are still wide enough to make epidemiologists weep.

“All models are just models,” Dr. Anthony S. Fauci, science adviser to the White House coronavirus task force, has said. “When you get new data, you change them.”

There may be good news buried in this inconsistency: The virus may also be mutating to cause fewer symptoms. In the movies, viruses become more deadly. In reality, they usually become less so, because asymptomatic strains reach more hosts. Even the 1918 Spanish flu virus eventually faded into the seasonal H1N1 flu.

At the moment, however, we do not know exactly how transmissible or lethal the virus is. But refrigerated trucks parked outside hospitals tell us all we need to know: It is far worse than a bad flu season.

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Commuters on the Staten Island Ferry.static01.nyt.com/images/2020/04/19/science/19VIRUS-FUTURE-p3/merlin_171637671_0a544e27-0c22-4a55-8c03-66843550de10-jumbo.jpg?quality=90&auto=webp 1024w, static01.nyt.com/images/2020/04/19/science/19VIRUS-FUTURE-p3/merlin_171637671_0a544e27-0c22-4a55-8c03-66843550de10-superJumbo.jpg?quality=90&auto=webp 2048w” sizes=”100vw” decoding=”async” itemprop=”url” itemid=”https://static01.nyt.com/images/2020/04/19/science/19VIRUS-FUTURE-p3/merlin_171637671_0a544e27-0c22-4a55-8c03-66843550de10-articleLarge.jpg?quality=75&auto=webp&disable=upscale” style=”margin: 0px; padding: 0px; border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: top; height: auto; max-width: 100%; width: 414px;” data-unique-identifier=””>
Credit…Misha Friedman for The New York Times

No one knows exactly what percentage of Americans have been infected so far — estimates have ranged from 3 percent to 10 percent — but it is likely a safe bet that at least 300 million of us are still vulnerable.

Until a vaccine or another protective measure emerges, there is no scenario, epidemiologists agreed, in which it is safe for that many people to suddenly come out of hiding. If Americans pour back out in force, all will appear quiet for perhaps three weeks.

Then the emergency rooms will get busy again.

“There’s this magical thinking saying, ‘We’re all going to hunker down for a while and then the vaccine we need will be available,’” said Dr. Peter J. Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine.

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In his wildly popular March 19 article in Medium, “Coronavirus: The Hammer and the Dance,” Tomas Pueyo correctly predicted the national lockdown, which he called the hammer, and said it would lead to a new phase, which he called the dance, in which essential parts of the economy could reopen, including some schools and some factories with skeleton crews.

Every epidemiological model envisions something like the dance. Each assumes the virus will blossom every time too many hosts emerge and force another lockdown. Then the cycle repeats. On the models, the curves of rising and falling deaths resemble a row of shark teeth.

Surges are inevitable, the models predict, even when stadiums, churches, theaters, bars and restaurants remain closed, all travelers from abroad are quarantined for 14 days, and domestic travel is tightly restricted to prevent high-intensity areas from reinfecting low-intensity ones.

The tighter the restrictions, experts say, the fewer the deaths and the longer the periods between lockdowns. Most models assume states will eventually do widespread temperature checks, rapid testing and contact tracing, as is routine in Asia.

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Even the “Opening Up America Again” guidelines Mr. Trump issued on Thursdayhave three levels of social distancing, and recommend that vulnerable Americans stay hidden. The plan endorses testing, isolation and contact tracing — but does not specify how these measures will be paid for, or how long it will take to put them in place.

On Friday, none of that stopped the president from contradicting his own message by sending out tweets encouraging protesters in Michigan, Minnesota and Virginia to fight their states’ shutdowns.

China did not allow Wuhan, Nanjing or other cities to reopen until intensive surveillance found zero new cases for 14 straight days, the virus’s incubation period. Compared with China or Italy, the United States is still a playground.

Americans can take domestic flights, drive where they want, and roam streets and parks. Despite restrictions, everyone seems to know someone discreetly arranging play dates for children, holding backyard barbecues or meeting people on dating apps.

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Partly as a result, the country has seen up to 30,000 new case infections each day. “People need to realize that it’s not safe to play poker wearing bandannas,” Dr. Schaffner said.

Even with rigorous measures, Asian countries have had trouble keeping the virus under control.

China, which has reported about 100 new infections per day, recently closed all the country’s movie theaters again. Singapore has closed all schools and nonessential workplaces. Japan recently declared a state of emergency. (South Korea has struggled at times, too, but on Sunday reported only eight new cases, the first single-digit increase in two months.)

Resolve to Save Lives, a public health advocacy group run by Dr. Thomas R. Frieden, the former director of the C.D.C., has published detailed and strict criteria for when the economy can reopen and when it must be closed.

Reopening requires declining cases for 14 days, the tracing of 90 percent of contacts, an end to health care worker infections, recuperation places for mild cases and many other hard-to-reach goals.

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“We need to reopen the faucet gradually, not allow the floodgates to reopen,” Dr. Frieden said. “This is a time to work to make that day come sooner.”

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Staff members of the Nido de Esperanza, a non-profit in the Washington Heights neighborhood of Manhattan, handed out food to families with small children.static01.nyt.com/images/2020/04/19/science/19VIRUS-FUTURE-p1/merlin_171637653_3a350a94-fb15-45aa-8c43-7ebb1551c1ad-jumbo.jpg?quality=90&auto=webp 1024w, static01.nyt.com/images/2020/04/19/science/19VIRUS-FUTURE-p1/merlin_171637653_3a350a94-fb15-45aa-8c43-7ebb1551c1ad-superJumbo.jpg?quality=90&auto=webp 2048w” sizes=”100vw” decoding=”async” itemprop=”url” itemid=”https://static01.nyt.com/images/2020/04/19/science/19VIRUS-FUTURE-p1/merlin_171637653_3a350a94-fb15-45aa-8c43-7ebb1551c1ad-articleLarge.jpg?quality=75&auto=webp&disable=upscale” style=”margin: 0px; padding: 0px; border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-caps: inherit; font-stretch: inherit; line-height: inherit; vertical-align: top; height: auto; max-width: 100%; width: 414px;” data-unique-identifier=””>
Credit…Misha Friedman for The New York Times

Imagine an America divided into two classes: those who have recovered from infection with the coronavirus and presumably have some immunity to it; and those who are still vulnerable.

“It will be a frightening schism,” Dr. David Nabarro, a World Health Organization special envoy on Covid-19, predicted. “Those with antibodies will be able to travel and work, and the rest will be discriminated against.”

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Already, people with presumed immunity are very much in demand, asked to donate their blood for antibodies and doing risky medical jobs fearlessly.

Soon the government will have to invent a way to certify who is truly immune. A test for IgG antibodies, which are produced once immunity is established, would make sense, said Dr. Daniel R. Lucey, an expert on pandemics at Georgetown Law School. Many companies are working on them.

Dr. Fauci has said the White House was discussing certificates like those proposed in Germany. China uses cellphone QR codeslinked to the owner’s personal details so others cannot borrow them.

The California adult-film industry pioneered a similar idea a decade ago. Actors use a cellphone app to prove they have tested H.I.V. negative in the last 14 days, and producers can verify the information on a password-protected website.

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As Americans stuck in lockdown see their immune neighbors resuming their lives and perhaps even taking the jobs they lost, it is not hard to imagine the enormous temptation to join them through self-infection, experts predicted. Younger citizens in particular will calculate that risking a serious illness may still be better than impoverishment and isolation.

“My daughter, who is a Harvard economist, keeps telling me her age group needs to have Covid-19 parties to develop immunity and keep the economy going,” said Dr. Michele Barry, who directs the Center for Innovation in Global Health at Stanford University.

It has happened before. In the 1980s, Cuba successfully contained its small AIDS epidemic by brutally forcing everyone who tested positive into isolation camps. Inside, however, the residents had their own bungalows, food, medical care, salaries, theater troupes and art classes.

Dozens of Cuba’s homeless youths infected themselves through sex or blood injections to get in, said Dr. Jorge Pérez Ávila, an AIDS specialist who is Cuba’s version of Dr. Fauci. Many died before antiretroviral therapy was introduced.

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It would be a gamble for American youth, too. The obese and immunocompromised are clearly at risk, but even slim, healthy young Americans have died of Covid-19.

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The next two years will proceed in fits and starts, experts said. As more immune people get back to work, more of the economy will recover.

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But if too many people get infected at once, new lockdowns will become inevitable. To avoid that, widespread testing will be imperative.

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Dr. Fauci has said “the virus will tell us” when it’s safe. He means that once a national baseline of hundreds of thousands of daily tests is established across the nation, any viral spread can be spotted when the percentage of positive results rises.

Detecting rising fevers as they are mapped by Kinsa’s smart thermometers may give an earlier signal, Dr. Schaffner said.

But diagnostic testing has been troubled from the beginning. Despite assurances from the White House, doctors and patients continue to complain of delays and shortages.

To keep the virus in check, several experts insisted, the country also must start isolating all the ill — including mild cases.

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